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RIP3 Antibody

CAT: 0800-R31366Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31366Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3), also known as RIP3, is an enzyme that in humans is encoded by the RIPK3 gene. This gene is mapped to 14q12. The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q9Y572
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the N-terminus of human RIP3 (EVKAMASLDNEFVLRLE) was used as the immunogen for this RIP3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the RIP3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This RIP3 antibody is available for research use only.
Storage Conditions
After reconstitution, the RIP3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the RIP3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of RIP3 antibody and Lane 1: PANC; 2: SW620; 3: SKOV-3; 4: M231 cell lysate
Product Datasheet
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