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MMP24 Antibody

CAT: 0800-R31336Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31336Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Matrix metalloproteinase-24, also known as MT5MMP and previously as MMP25, is an enzyme that in humans is encoded by the MMP24 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. This gene may be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q9Y5R2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the N-terminus of human Matrix metalloproteinase-24 (YHEIKSDRKEADIMIFFA) was used as the immunogen for this MMP24 antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the MMP24 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MMP24 antibody is available for research use only.
Storage Conditions
After reconstitution, the MMP24 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the MMP24 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of MMP24 antibody and Lane 1: PANC; 2: HeLa; 3: SMMC-7721; 4: A549 cell lysate
Product Datasheet
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