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PTH1R Antibody

CAT: 0800-R31247Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31247Size:100 µg
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Description
Parathyroid hormone/parathyroid hormone-related peptide receptor, also known as PTHR, is a protein that in humans is encoded by the PTH1R gene. PTHR is a member of a family of G protein-coupled receptors. PTHR gene was mapped to the vicinity of the 3p21.3-p21.2 boundary by PCR analysis of human/rodent somatic cell hybrid panels using oligonucleotide primers designed to amplify a portion of the gene from genomic DNA. This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. PTH1R functions as a receptor for parathyroid hormone and for parathyroid hormone-related protein.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 0.5-1 µg/mL, Immunocytochemistry: 0.5-1 µg/mL
UniProt
Q03431
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the C-terminus of human Parathyroid Hormone Receptor 1 (KLRETNAGRCDTRQQYRKL) was used as the immunogen for this PTH1R antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ICC
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the PTH1R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PTH1R antibody is available for research use only.
Storage Conditions
After reconstitution, the PTH1R antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the PTH1R antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human 1) SK-OV-3, 2) U-2 0S, 3) HeLa and 4) SMMC-7721 cell lysate. Expected molecular weight ~66 kDa (unmodified), 85-95 kDa (glycosylated) .

UniProtKB · Q03431

Parathyroid hormone/parathyroid hormone-related peptide receptor

PTH1R_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q03431
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTH1R
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q2M1U3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneMembrane

Disease

Disease variantDwarfism

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

G protein-coupled receptorReceptorTransducer

Domain

SignalTransmembraneTransmembrane helix

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