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P53R2 Antibody

CAT: 0800-R31164Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31164Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ribonucleotide Reductase, M2 B, also known as P53R2, is an enzyme that in humans is encoded by the RRM2B gene. Tanaka et al. (2000) mapped the gene to chromosome 8q23.1 by fluorescence in situ hybridization. Tanaka et al. (2000) found that expression of p53R2, but not R2, was induced by ultraviolet and gamma-irradiation and adriamycin treatment in a wildtype p53-dependent manner. Induction of p53R2 in p53-deficient cells caused G2/M arrest and protected cells from death in response to adriamycin. Inhibition of endogenous p53R2 expression in cells that had an intact p53-dependent DNA damage checkpoint reduced ribonucleotide reductase activity, DNA repair, and cell survival after exposure to various genotoxins.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q7LG56
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the C-terminus of human p53 reductase small subunit 2 (EGKTNFFEKRVSEYQ) was used as the immunogen for this p53R2 antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the p53R2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This p53R2 antibody is available for research use only.
Storage Conditions
After reconstitution, the p53R2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the p53R2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of p53R2 antbody; Lane 1: rat thymus; 2: human MCF-7; 3: (h) A431; 4: (h) HeLa cell lysate. Expected/observed size ~40KD

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