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RSK1 Antibody

CAT: 0800-R31163Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31163Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ribosomal Protein S6 Kinase, 90-KD, 1, also called RSK1, is an enzyme that in humans is encoded by the RPS6KA1 gene. The RSK (ribosomal S6 kinase) family comprises growth factor-regulated serine/threonine kinases, known also as p90 (RSK) . Homologs exist in several species. By analysis of somatic cell hybrids, Moller et al. (1994) mapped the gene to chromosome 3. Bonni et al. (1999) characterized the mechanism by which the RAS-MAPK signaling pathway mediates growth factor-dependent cell survival. Inoue et al. (2007) demonstrated that p90RSK, the kinase immediately downstream from Mos-MAPK, directly targets Erp1 for CSF arrest in Xenopus oocytes.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q15418
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the C-terminus of human RSK1 (ILAQRRVRKLPSTTL) was used as the immunogen for this RSK1 antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the RSK1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This RSK1 antibody is available for research use only.
Storage Conditions
After reconstitution, the RSK1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the RSK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Nuclear, cytoplasmic
Image Legend
Western blot testing of RSK1 antbody; Lane 1: MCF-7; 2: HeLa; 3: K562; 4: Jurkat; 5: SW620; 6: Raji cell lysate. Predicted molecular weight: 83~90 kDa.

UniProtKB · Q15418

Ribosomal protein S6 kinase alpha-1

KS6A1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15418
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RPS6KA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
S6K-alpha-1
EC number
2.7.11.1
Processing
—
Secondary accessions
A6NGG4, A8K9K7, B2RDY8, B7Z5J0, E9PRI4, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Biological process

Cell cycleHost-virus interactionStress response

Cellular component

CytoplasmNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

Domain

Repeat

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