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Periostin Antibody

CAT: 0800-R31158Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31158Size:100 µg
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Description
POSTN (Periostin), also known as PN or OSF2, is a protein that in humans is encoded by the POSTN gene. The International Radiation Hybrid Mapping Consortium mapped the POSTN gene to chromosome 13. Gillan et al. (2002) found that purified recombinant PN supported adhesion of ovarian epithelial cells. Shao et al. (2004) found that periostin was overexpressed by the majority of human primary breast cancers examined. Transfected tumor cell lines overexpressing periostin showed accelerated growth and angiogenesis as xenografts in immunocompromised animals. Kuhn et al. (2007) showed that extracellular periostin induced reentry of differentiated mammalian cardiomyocytes into the cell cycle.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q62009
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
An amino acid sequence from the N-terminus of mouse Periostin (NSYYDKVLAHSRIRGRDQ) was used as the immunogen for this Periostin antibody (100% rat homology) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Periostin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Periostin antibody is available for research use only.
Storage Conditions
After reconstitution, the Periostin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the Periostin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Periostin antbody and mouse heart. Predicted molecular weight ~93 kDa.

UniProtKB · Q62009

Periostin

POSTN_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q62009
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Postn
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
PN
EC number
—
Processing
Precursor
Secondary accessions
Q8BMJ6, Q8K1K0
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

PTM

Disulfide bondGamma-carboxyglutamic acidGlycoprotein

Cellular component

Extracellular matrixGolgi apparatusSecreted

Molecular function

Heparin-binding

Technical term

Reference proteome

Domain

RepeatSignal

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