Beta Arrestin 2 Antibody

CAT: 0800-R30943Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0800-R30943Size:100 µg

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Description

Beta Arrestin 2 is an intracellular protein that in humans is encoded by the ARRB2 gene. Members of the arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals, as well as having signalling roles in their own right. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptorfunction in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Beta-arrestins were originally discovered in the context of heterotrimeric G protein-coupled receptor desensitization, but they also function in internalization and signaling of these receptors.

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL

UniProt

P32121

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

An amino acid sequence from the C-terminus of human ARRB2 (RLKGMKDDDYDDQLC) was used as the immunogen for this Beta Arrestin 2 antibody. This sequence is common to isoforms 1-5 of P32121 (UniProt) .

Clonality

Polyclonal

Isotype

IgG

Applications

WB, IHC-P

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal

Reconstitution

After reconstitution, the Beta Arrestin 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This Beta Arrestin 2 antibody is available for research use only.

Storage Conditions

After reconstitution, the Beta Arrestin 2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

The stated application concentrations are suggested starting amounts. Titration of the Beta Arrestin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

Western blot testing of Beta Arrestin 2 antibody and Lane 1: human HeLa; 2: rat skeletal muscle. Predicted molecular weight: 44~47kDa (isoforms 1-5) .

UniProtKB · P32121

Beta-arrestin-2

ARRB2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P32121
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ARRB2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B4DLW0, B5B0C0, B7WPL3, D3DTK2, H0Y688, Q0Z8D3, Q2PP19, Q6ICT3, Q8N7Y2, Q9UEQ6

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCoated pitCytoplasmCytoplasmic vesicleMembraneNucleus

PTM

HydroxylationPhosphoproteinUbl conjugation

Biological process

Protein transportTransport

Molecular function

Signal transduction inhibitor

Product Datasheet

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