Products for Research Use Only
RegisterLogin

Aurora A Antibody

CAT: 0800-R30880Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-R30880Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Aurora kinase A, also called ARK1, AURKA, AIK , AURORA2 , BTAK, PPP1R47, STK7, STK15, and STK6, is a mitotic centrosomal protein kinase. The main role of AURKA in tumor development is in controlling chromosome segregation during mitosis. Aurora A is a member of a family of mitotic serine/threonine kinases. Cell cycle and Northern blot analyses showed that peak expression of the protein occurs during the G2/M phase and then decreases. By fluorescence in situ hybridization, the gene is represented by 2 signals in chromosome bands 20q13.2-q13.3 and 1q41-q42. It is overexpressed in many human cancers. Ectopic overexpression of Aurora A in mammalian cells induces centrosome amplification, chromosome instability, and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53. Depletion of Ajuba prevented activation of AURKA at centrosomes in late G2 phase and inhibited mitotic entry. Activation of the kinase was independently sufficient to induce rapid ciliary resorption, and AURKA acted in this process through phosphorylation of HDAC6, leading to HDAC6-dependent tubulin deacetylation and destabilization of the ciliary axoneme.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P97477
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
An amino acid sequence from the middle region of mouse AURKA (QKTEDTKKRQWTLEDFD) was used as the immunogen for this Aurora A antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Aurora A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Aurora A antibody is available for research use only.
Storage Conditions
After reconstitution, the Aurora A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the Aurora A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, nuclear
Image Legend
Western blot testing of Aurora A antibody at and mouse ovary lysate. Expected molecular weight: ~46kDa.
Product Datasheet
Loading...

Related Products

CatalogName
RQ4718AURKA Antibody / Aurora-A
V3927-100UGAURKB Antibody / Aurora B
V3927-20UGAURKB Antibody / Aurora B
V3927SAF-100UGAURKB Antibody / Aurora B
V7296-20UGRecombinant AURKB Antibody / Aurora B
V7296IHC-7MLRecombinant AURKB Antibody / Aurora B
RQ7273Ark-1 Antibody / Aurora-related kinase 1 / Aurka
V7296-100UGRecombinant AURKB Antibody / Aurora B
V7296SAF-100UGRecombinant AURKB Antibody / Aurora B
R20468-0.1MLPhospho-Aurora A/B/C Antibody (pThr288/pThr232/pThr198)

Alternative Products

CatalogName
abx133082-01Aurora B (Aurora B) Antibody
20R-2159Aurora A antibody
KC-2618-01Aurora-A Antibody
HY-P80442Aurora A Antibody (YA595)
MBS8533865-01Aurora A

Popular Products