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MCM6 Antibody

CAT: 0800-R30862Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30862Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Minichromosome maintenance, s. pombe, homolog of, 6 is a protein that in humans is encoded by the MCM6 gene. It is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The MCM genes were originally identified in yeast defective in minichromosome maintenance and have since been shown to play roles in the progression of the cell cycle; many are cell division control genes. MCM6 has recently been shown to interact strongly Cdt1 at defined residues by mutating these target residues. Wei et al. observed lack of Cdt1 recruitment of MCM2-7 to the pre-RC. An approximately 200-kb region surrounding the C/T (-13910) polymorphism in MCM6 intron 13 functioned as an enhancer of the lactase gene promoter in intestinal cell culture.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 0.5-1 µg/mL, Immunohistochemistry (Frozen) : 0.5-1 µg/mL, Immunocytochemistry: 0.5-1 µg/mL, Immunofluorescence: 2-4 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
Q14566
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the middle region of human MCM6 (ESEDFIVEQYKHLRQRD) was used as the immunogen for this MCM6 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IHC-F, ICC, IF, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the MCM6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MCM6 antibody is available for research use only.
Storage Conditions
After reconstitution, the MCM6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the MCM6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Nuclear
Image Legend
Western blot testing of MCM6 antibody and Lane 1: U87; 2: COLO320; 3: HeLa; 4: MCF-7; 5: Jurkat cell lysate. Expected molecular weight: 92-105 kDa.

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