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SDHB Antibody

CAT: 0800-R30808Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30808Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Succinate Dehydrogenase Complex, Subunit B, iron sulfur protein is a protein that in humans is encoded by the SDHB gene. It is one of four protein subunits forming succinate dehydrogenase, the other three being SDHA, SDHC and SDHD. The SDHB subunit is connected to the SDHA subunit on the hydrophilic, catalytic end of the SDH complex. The entire SDHB transcript is encoded by 8 exons within approximately 40 kb by Au et al (1995) . Pollard et al. (2005) stated that the nuclear-encoded Krebs cycle enzymes fumarate hydratase and succinate dehydrogenases like SDHB act as tumor suppressors, and germline mutations in these genes predispose individuals to leiomyomas and renal cancer and to paragangliomas, respectively. In affected members of families with paragangliomas-4, mutations were identified in the SDHB gene.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL
UniProt
P21912
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 42-59 (FAIYRWDPDKAGDKPHMQ-human) were used as the immunogen for this SDHB antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the SDHB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This SDHB antibody is available for research use only.
Storage Conditions
After reconstitution, the SDHB antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the SDHB antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
IHC staining of FFPE human lung adenocarcinoma tissue with SDHB antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

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