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SOCS3 Antibody

CAT: 0800-R30796Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30796Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Suppressor of cytokine signaling 3 is a protein that in humans is encoded by the SOCS3 gene. It is transiently expressed by multiple cell lineages within the immune system and functions predominantly as a negative regulator of cytokines that activate the JAK-STAT3 pathway. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN) -gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
O14543
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
An amino acid sequence from the middle region of human SOCS3 (RDSSDQRHFFTLSVK) was used as the immunogen for this SOCS3 antibody (100% mouse homology) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the SOCS3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This SOCS3 antibody is available for research use only.
Storage Conditions
After reconstitution, the SOCS3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the SOCS3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of SOCS3 antibody and Lane 1: Jurkat; 2: CEM; 3: Raji cell lysate. Predicted molecular weight ~24kDa.

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