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LCN1 Antibody

CAT: 0800-R30744Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30744Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lipocalin-1, also known as PREALBUMIN, TEAR or VEGP, is a protein that in humans is encoded by the LCN1 gene. Lipocalin-1 is a member of the lipocalin family of small secretory proteins, which is mapped on 9q34.3. It is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. It may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. LCN1 inhibits the cysteine-protease papain in vitro, similar to cystatins. And it plays a role in the nonimmunologic defense and in the control of inflammatory processes in oral and ocular tissues. The investigations presented the first clear evidence that LCN1 is induced in infection or inflammation and supported the idea that this lipocalin functions as a physiologic protection factor of epithelia in vivo.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P31025
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the middle region of human LCN1 (HVKDHYIFYCEGELH) was used as the immunogen for this LCN1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the LCN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This LCN1 antibody is available for research use only.
Storage Conditions
After reconstitution, the LCN1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the LCN1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of LCN1 antibody and Lane 1: Jurkat; 2: COLO320; 3: SCG; 4: HeLa cell lysate

UniProtKB · P31025

Lipocalin-1

LCN1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P31025
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LCN1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q5T8A1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Disulfide bond

Cellular component

Secreted

Biological process

Sensory transductionTasteTransport

Domain

Signal

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