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IL3RA Antibody / CD123

CAT: 0800-R30698Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30698Size:100 µg
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Description
IL3RA (Interleukin 3 receptor alpha), also called CD123 (Cluster of Differentiation 123), is a human gene. The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor which is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5) . The genomic structures of IL3RA and CSF2RA are very similar and share an additional exon encoding part of the C-terminal domain not found in other members of this gene family. As in human hematopoietic cells, IL3 and GMCSF competed for binding in fibroblasts expressing the cDNAs for IL3RA, CSF2RA, and the common beta subunit, indicating that different alpha subunits compete for a common beta subunit.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P26951
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the middle region of human IL3RA (QYDLYLNVANRRQQYEC) was used as the immunogen for this IL3RA antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the IL3RA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This IL3RA antibody is available for research use only.
Storage Conditions
After reconstitution, the IL3RA antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the IL3RA antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of IL3RA antibody and Lane 1: A431 cell lysate ; 2: SMMC-7721; 3: U87; 4: 293T cell lysate. Predicted molecular weight ~43kDa.

UniProtKB · P26951

Interleukin-3 receptor subunit alpha

IL3RA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P26951
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL3RA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA
EC number
—
Processing
Precursor
Secondary accessions
A8K3F3, B9VI81, Q5HYQ7, Q5HYQ8, Q9UEH7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinUbl conjugation

Molecular function

Receptor

Domain

SignalTransmembraneTransmembrane helix

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