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EphA1 Antibody

CAT: 0800-R30649Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30649Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EPH receptor A1, is a protein that in humans is encoded by the EPHA1 gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. The gene is mapped to 7q34-q35. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. They are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P21709
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the C-terminus of human EphA1 (HQKRILCSIQGFKD) was used as the immunogen for this EphA1 antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the EphA1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This EphA1 antibody is available for research use only.
Storage Conditions
After reconstitution, the EphA1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the EphA1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of EphA1 antibody and Lane 1: rat liver; 2: (r) lung; 3: (r) intestine; 4: (r) ovary; 5: U87; 6: A549; 7: COLO320; 8: SW620; 9: HeLa cell lysate. Predicted molecular weight: ~108kDa.

UniProtKB · P21709

Ephrin type-A receptor 1

EPHA1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P21709
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EPHA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hEpha1
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
A1L3V3, B5A966, B5A967, Q15405
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AngiogenesisCell adhesion

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneMembrane

PTM

GlycoproteinPhosphoproteinUbl conjugation

Molecular function

KinaseReceptorTransferaseTyrosine-protein kinase

Domain

RepeatSignalTransmembraneTransmembrane helix

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