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CTBP1 Antibody

CAT: 0800-R30646Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30646Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C-terminal-binding protein 1 is encoded by the CTBP1 gene. It binds to the C-terminus of adenovirus E1A proteins. It is a transcriptional repressor (corepressor) and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. CtBP1 and CtBP2 preferentially associate with the E1A via a 5 amino acid motif, PLDLS, to repress E1A induced oncogenesis and cellular transformation. CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. During skeletal and T cell development, CtBP1 and -2 associate with the PLDLSL domain of delta EF1, a cellular zinc finger-homeodomain protein, and thereby enhances delta EF1-induced transcriptional silencing. In addition, CtBP complexes with CtIP, a 125 kDa protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
Q13363
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 425-440 (QTVKPEADRDHASDQL-human) were used as the immunogen for this CTBP1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the CtBP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CTBP1 antibody is available for research use only.
Storage Conditions
After reconstitution, the CTBP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the CTBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of CTBP1 antibody and Lane 1: rat brain; 2: rat testis; 3: rat ovary; 4: U87; 5: SW620; 6: HT1080; 7: COLO320 cell lysate. Predicted/observed molecular weight: ~47kDa.
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