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BAFF Antibody

CAT: 0800-R30618Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30618Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF) -related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFFR) . BAFF was regularly detected by enzyme-linked immunosorbent assay in brain tissue lysates and in normal spinal fluid, and in astrocytes by double fluorescence microscopy. It is localized in astrocytes close to BAFFR-expressing immune cells. BAFF receptors were strongly expressed in situ in primary central nervous system (CNS) lymphomas. The protein plays an important role in humoral immunity and in autoimmune diseases, including RA. Local gene targeting inhibited proinflammatory cytokine expression, suppressed generation of plasma cells and Th17 cells, and markedly ameliorated joint pathology.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
Q9Y275
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 265-285 (RENAQISLDGDVTFFGALKLL-human) were used as the immunogen for this BAFF antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the BAFF antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This BAFF antibody is available for research use only.
Storage Conditions
After reconstitution, the BAFF antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the BAFF antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of BAFF antibody and Lane 1: recombinant human protein 10ng; 2: 5ng; 3: 2.5ng

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