Products for Research Use Only

BLyS Antibody / BAFF

CAT: 0800-RQ5555Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ5555Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BLyS / BAFF was regularly detected by enzyme-linked immunosorbent assay in brain tissue lysates and in normal spinal fluid, and in astrocytes by double fluorescence microscopy. BAFF was localized in astrocytes close to BAFF-R-expressing immune cells. BAFF receptors were strongly expressed in situ in primary central nervous system (CNS) lymphomas. The TNF superfamily member B cell-activating factor (BAFF) plays an important role in humoral immunity and in autoimmune diseases, including RA. Local BAFF gene targeting inhibited proinflammatory cytokine expression, suppressed generation of plasma cells and Th17 cells, and markedly ameliorated joint pathology. The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF) -related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R) .
CAS Number
9007-83-4
Specifications
Western blot: 0.25-0.5 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q9Y275
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A human recombinant protein (amino acids A134-T277) was used as the immunogen for the BLyS antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the BLyS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This BLyS antibody is available for research use only.
Storage Conditions
After reconstitution, the BLyS antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the BLyS antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) U-937, 2) Caco-2, 3) PANC-1, 4) CCRF-CEM, 5) MDA-MB-231 lysate with BLyS antibody. Predicted molecular weight ~34 kDa.