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IP10 Antibody / CXCL10

CAT: 0800-R30467Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30467Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C-X-C motif chemokine 10 (CXCL10), also known as Interferon gamma-induced protein 10 kDa (IP10) or small-inducible cytokine B10, is a protein that in humans is encoded by the CXCL10 gene. It is a small cytokine belonging to the CXC chemokine family. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. Luster et al. (1987) reported the isolation of an interferon-inducible gene that encodes a 98-amino acid protein called IP10. The chemokine IFN-gamma-inducible protein 10, a CXC chemokine, and its receptor, CXCR3, were found to be overexpressed in lymph node cells of EAMG rats. IP10 inhibits bone marrow colony formation, has antitumor activity in vivo, is a chemoattractant for human monocytes and T cells, and promotes T cell adhesion to endothelial cells.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P02778
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids 79-98 (SKAIKNLLKAVSKERSKRSP-human) were used as the immunogen for this IP10 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the IP10 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This IP10 antibody is available for research use only.
Storage Conditions
After reconstitution, the IP10 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the IP10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of IP10 antibody and Lane 1: recombinant human protein 10ng; 2: 5ng; 3: 2.5ng

UniProtKB · P02778

C-X-C motif chemokine 10

CXL10_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02778
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CXCL10
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q96QJ5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

ChemotaxisInflammatory response

PTM

CitrullinationDisulfide bond

Molecular function

Cytokine

Cellular component

Secreted

Domain

Signal

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