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Cyclin D1 Antibody

CAT: 0800-R30348Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30348Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-type cyclins are regarded as essential links between cell environment and the core cell cycle machinery. Cyclin D1, the product of the human gene CCND1, is also known as BCL1. Cyclin D1 expression is regulated by the retinoblastoma protein. Expression of Cyclin D1, but not of cyclins A and E, was induced by transfection of the RB gene into RB-deficient tumor cells. The CCND1 gene can function as an oncogene.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P25322
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 219-238 (SPNNFLSCYRTTHFLSRVIK) were used as the immunogen for this Cyclin D1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Cyclin D1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Cyclin D1 antibody is available for research use only.
Storage Conditions
After reconstitution, the Cyclin D1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Cyclin D1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Cyclin D1 antibody and Lane 1: rat testis; 2: rat ovary; 3: rat brain; 4: HeLa; 5: MM231; 6: SW620 cell lysate. Predicted molecular weight: 32-36 kDa.

UniProtKB · P25322

G1/S-specific cyclin-D1

CCND1_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P25322
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Ccnd1
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Biological process

Cell cycleCell divisionTranscriptionTranscription regulation

Molecular function

CyclinRepressor

Cellular component

CytoplasmMembraneNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Technical term

Reference proteome

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