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MBP Antibody / Myelin Basic Protein

CAT: 0800-R30229Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30229Size:100 µg
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Description
Myelin basic protein (MBP) is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the central nervous system and the peripheral nervous system, respectively. It is most abundant in hemopoietic system and contains seven exons distributed over 32-34 kb. MBP isolated from MS brain may differ in charge microheterogeneity which would affect antigenic determinants. MBP is mapped to chromosome 18q22-23. Failure in this gene expression would be correlated in the central white matter with extrapyramidal system degeneration signs. Moreover, it is a candidate autoantigen in the disease multiple sclerosis.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence (FFPE) : 2-4 µg/mL
UniProt
P02686
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
Amino acids KLGGRDSRSGSPMARR were used as the immunogen for this MBP antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the MBP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MBP antibody is available for research use only.
Storage Conditions
After reconstitution, the MBP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the MBP antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of MBP antibody and mouse brain tissue lysate. Multiple isoforms may be visualized from 20~37 kDa.

UniProtKB · P02686

Myelin basic protein

MBP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02686
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MBP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MBP
EC number
—
Processing
—
Secondary accessions
A4FU54, A6NI84, A8MY86, A8MYL4, B3KY66, B7ZKS2, B7ZKS4, Q15337, Q15338, Q15339, Q15340, Q59GX3, Q65ZS4, Q6AI64, Q6FH37, Q6FI04, Q6PK23
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationCitrullinationMethylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Disease

Autoimmune encephalomyelitis

Cellular component

Cell membraneMembraneNucleus

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