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Occludin Antibody

CAT: 0800-R30159Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30159Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Occludin is an integral membrane protein that is located at tight junctions. It is a member of a family of proteins containing the highly conserved Marvel domain, which contains 4 transmembrane-helix regions. This gene is mapped to 5q13.2. Occludin regulates TGF-beta receptor type I localization for efficient TGF-beta-dependent dissolution of tight junctions during epithelial-mesenchymal transitions. It is an essential hepatitis C virus (HCV) cell entry factor that is able to render murine cells infectable with HCV glycoproteins. It has been found that Occludin is involved in cell migration and functions to recruit active PI3 kinase to the leading edge, resulting in RAC1 activation and formation of lamellipodia.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
Q16625
Host
Rabbit
Reactivity
Human
Immunogen
Human partial recombinant protein (AA 373-522) was used as the immunogen for this Occludin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the Occludin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Occludin antibody is available for research use only.
Storage Conditions
After reconstitution, the Occludin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Occludin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Occludin antibody and Lane 1: SW620; 2: COLO320; 3: A549; 4: 293T; 5: U87. Predicted molecular weight ~59 kDa.

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