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Haptoglobin Antibody / HP

CAT: 0800-F55010-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F55010-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HP is a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1:10-1:50 (1x10e6 cells), Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE) : 1:50-1:100
UniProt
P00738
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 295-322 from the human protein was used as the immunogen for the Haptoglobin antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
FACS, WB, IHC-P
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Haptoglobin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Haptoglobin antibody is available for research use only.
Storage Conditions
Aliquot the Haptoglobin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Haptoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human liver tissue lysate with Haptoglobin antibody. Predicted molecular weight: 45, 38 kDa (two isoforms) .

UniProtKB · P00738

Haptoglobin

HPT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P00738
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B0AZL5, P00737, Q0VAC4, Q0VAC5, Q2PP15, Q3B7J0, Q6LBY9, Q9UC67
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Acute phaseImmunity

Coding sequence diversity

Alternative splicing

Molecular function

AntibioticAntimicrobialAntioxidantSerine protease homolog

Disease

Disease variant

PTM

Disulfide bondGlycoprotein

Ligand

Hemoglobin-binding

Domain

RepeatSignalSushi

Cellular component

Secreted

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