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P38 MAPK Antibody / MAPK14

CAT: 0800-F54913-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F54913-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000-1:2000, Flow cytometry: 1:25 (1x10e6 cells)
UniProt
Q16539
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A portion of amino acids 301-330 from the human protein was used as the immunogen for the p38 MAPK antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the p38 MAPK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This p38 MAPK antibody is available for research use only.
Storage Conditions
Aliquot the p38 MAPK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the p38 MAPK antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of 1) human HepG2, 2) human HeLa, 3) rat PC-12, 4) human Jurkat, 5) human MCF7 and 6) mouse kidney lysate with p38 MAPK antibody. Expected molecular weight: 38-41 kDa.

UniProtKB · Q16539

Mitogen-activated protein kinase 14

MK14_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16539
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAPK14
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MAP kinase 14, MAPK 14
EC number
2.7.11.24
Processing
—
Secondary accessions
A6ZJ92, A8K6P4, B0LPH0, B5TY32, O60776, Q13083, Q14084, Q8TDX0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisStress responseTranscriptionTranscription regulation

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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