Products for Research Use Only

OASIS Antibody / CREB3L1

CAT: 0800-F54862-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F54862-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CREB3L1 is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. It is specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity) . It may play a role in gliosis. In vitro, it binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1:50-1:100, Flow cytometry: 1:10-1:50 (1x10e6 cells), Western blot: 1:2000-1:8000
UniProt
Q96BA8
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 481-509 from the human protein was used as the immunogen for the OASIS antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC-P, FACS, WB
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the OASIS antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This OASIS antibody is available for research use only.
Storage Conditions
Aliquot the OASIS antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the OASIS antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, nuclear
Image Legend
Western blot testing of human HepG2 cell lysate with OASIS antibody. Predicted molecular weight ~57 kDa. The ~47 kDa isoform may also be visualized.

UniProtKB · Q96BA8

Cyclic AMP-responsive element-binding protein 3-like protein 1

CR3L1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96BA8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CREB3L1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
cAMP-responsive element-binding protein 3-like protein 1
EC number
—
Processing
—
Secondary accessions
Q8N2D5, Q96CP0
Protein keywords

Molecular function

ActivatorDevelopmental proteinDNA-binding

Coding sequence diversity

Alternative splicing

Cellular component

Endoplasmic reticulumMembraneNucleus

PTM

GlycoproteinIsopeptide bondUbl conjugation

Biological process

Host-virus interactionTranscriptionTranscription regulationUnfolded protein response

Disease

Osteogenesis imperfecta

Technical term

Proteomics identificationReference proteome

Domain

Signal-anchorTransmembraneTransmembrane helix
Product Datasheet
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