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HOMER3 Antibody

CAT: 0800-F54437-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F54437-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HOMER3 is a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. This protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides.
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:2000, Flow cytometry: 1:25 (1x10e6 cells), Immunohistochemistry (FFPE) : 1:25
UniProt
Q9NSC5
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 281-308 from the human protein was used as the immunogen for the HOMER3 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS, IHC-P
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the HOMER3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This HOMER3 antibody is available for research use only.
Storage Conditions
Aliquot the HOMER3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the HOMER3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, cell junction
Image Legend
IHC testing of FFPE human brain tissue with HOMER3 antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.

UniProtKB · Q9NSC5

Homer protein homolog 3

HOME3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NSC5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HOMER3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Homer-3
EC number
—
Processing
—
Secondary accessions
B2RA10, E9PCW9, O14580, O95350, Q9NSB9, Q9NSC0, Q9NSC1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Domain

Coiled coil

Cellular component

CytoplasmSynapse

PTM

Phosphoprotein
Product Datasheet
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