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Exportin 2 Antibody / CSE1L

CAT: 0800-F54382-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F54382-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, CSE1L may play a role both in apoptosis and in cell proliferation.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1:25, Immunofluorescence: 1:25, Western blot: 1:500-1:2000
UniProt
P55060
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 55-84 from the human protein was used as the immunogen for the Exportin 2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC-P, IF, WB
Purity
SAS precipitation
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Exportin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Exportin 2 antibody is available for research use only.
Storage Conditions
Aliquot the Exportin 2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Exportin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Nuclear, cytoplasmic
Image Legend
Western blot testing of human 1) HeLa, 2) Jurkat, 3) Ramos and 4) mouse NIH 3T3 cell lysate with Exportin 2 antibody. Predicted molecular weight ~110 kDa.

UniProtKB · P55060

Exportin-2

XPO2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P55060
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CSE1L
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Exp2
EC number
—
Processing
—
Secondary accessions
A3RLL6, B2R5T4, E1P5Y0, F8W904, O75432, Q32M40, Q9H5B7, Q9NTS0, Q9UP98, Q9UP99, Q9UPA0
Protein keywords

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Technical term

Direct protein sequencingProteomics identificationReference proteome

Biological process

Protein transportTransport
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