Exportin 2 antibody / CSE1L

Exportin 2 antibody / CSE1L

• Description: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, CSE1L may play a role both in apoptosis and in cell proliferation.
• CAS Number: 9007-83-4
• UniProt: P55060
• Host: Rabbit
• Immunogen: A portion of amino acids 55-84 from the human protein was used as the immunogen for the Exportin 2 antibody.
• Clonality: Polyclonal
• Isotype: Ig
• Applications: IHC-P, IF, WB
• Format: Purified
• Buffer: In 1X PBS, pH 7.4, with 0.09% sodium azide
• Reconstitution: Aliquot the Exportin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This Exportin 2 antibody is available for research use only.