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ATG16L Antibody

CAT: 0800-F54288-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F54288-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole) . The APG12-APG5-APG16L complex is esential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane.
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:25, Immunofluorescence: 1:25
UniProt
Q676U5
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 161-190 from the human protein were used as the immunogen for the ATG16L1 Antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P, IF
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ATG16L1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ATG16L1 antibody is available for research use only.
Storage Conditions
Aliquot the ATG16L1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the ATG16L1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
Western blot testing of human Jurkat lysate with ATG16L1 antibody. Predicted molecular weight ~68 kDa.

UniProtKB · Q676U5

Autophagy-related protein 16-1

A16L1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q676U5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ATG16L1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A3EXK9, A3EXL0, B6ZDH0, Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AutophagyProtein transportTransport

Domain

Coiled coilRepeatWD repeat

Cellular component

CytoplasmEndosomeLysosomeMembrane

PTM

Phosphoprotein

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