Pyruvate Kinase Antibody / PKM2

• Description:

  Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. [UniProt]

• UniProt:

  P14618

• Host:

  Mouse

• Immunogen:

  A human recombinant partial protein was used as the immunogen for this PKM2 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Applications:

  WB, ICC/IF

• Format:

  Purified

• Buffer:

  Antibody in PBS with 50% Glycerol and 0.03% ProClin 300

• Reconstitution:

  Store the PKM2 antibody at -20oC.

• Limitations:

  This PKM2 antibody is available for research use only.

• CAS Number:

  9007-83-4