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COPS7B Antibody / CSN7b

CAT: 0800-F53955-0.2MLSize: 0.2 mLDry Ice: NoHazardous: No
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CAT#:0800-F53955-0.2MLSize:0.2 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COP9 signalosome complex subunit 7b is a component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:1000
UniProt
Q9H9Q2
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 223-257 from the human protein was used as the immunogen for the COPS7B antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the COPS7B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This COPS7B antibody is available for research use only.
Storage Conditions
Aliquot the COPS7B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the COPS7B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Bovine
Image Legend
Western blot testing of human 1) Jurkat and 2) HL-60 cell lysate with COPS7B antibody at 1:1000. Predicted molecular weight: 30 kDa.
Product Datasheet
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