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E-Cadherin Antibody / CDH1

CAT: 0800-F53810-0.2MLSize: 0.2 mLDry Ice: NoHazardous: No
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CAT#:0800-F53810-0.2MLSize:0.2 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-Cadherin/CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
CAS Number
9007-83-4
Specifications
Western blot: 1:2000-4000, IHC (FFPE) : 1:25
UniProt
P12830
Host
Mouse
Reactivity
Human
Immunogen
A human recombinant protein of amino acids 1-392 was used as the immunogen for the E-Cadherin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1579CT577.150.80
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the E-Cadherin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This E-Cadherin antibody is available for research use only.
Storage Conditions
Aliquot the E-Cadherin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the E-Cadherin antibody may be required due to differences in protocols and substrate sensitivity.
Location
Cytoplasmic, membranous
Image Legend
Western blot testing of human 1) A431 and 2) T47D cell lysate with E-Cadherin antibody at 1:4000. Expected molecular weight: ~135 kDa (precursor), 80-120 kDa (mature, depending on glycosylation level) .

UniProtKB · P12830

Cadherin-1

CADH1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P12830
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CDH1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A8K1U7, Q13799, Q14216, Q15855, Q16194, Q4PJ14, Q9UII8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Biological process

Cell adhesion

Cellular component

Cell junctionCell membraneCytoplasmEndosomeGolgi apparatusMembraneSecreted

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoproteinUbl conjugation

Disease

Disease variantEctodermal dysplasia

Domain

RepeatSignalTransmembraneTransmembrane helix

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