FOXA1 Antibody

CAT: 0800-F53685-0.1MLSize: 0.1 mLDry Ice: NoHazardous: No
CAT#:0800-F53685-0.1MLSize:0.1 mL
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Description
FOXA1 is a transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity) . Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity) . Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:100-1:200
UniProt
P55317
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 143-171 from the human protein was used as the immunogen for this FOXA1 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
596CT18.4.3
Applications
WB, ELISA
Purity
Ascites
Format
Ascites
Buffer
In ascites with 0.09% sodium azide
Reconstitution
Aliquot the FOXA1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This FOXA1 antibody is available for research use only.
Storage Conditions
Aliquot the FOXA1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In ascites with 0.09% sodium azide
Applications Notes
Titration of the FOXA1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse, Rat
Image Legend
FOXA1 antibody western blot analysis in HeLa lysate. Predicted molecular weight: ~49 kDa.

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