SOX7 Antibody

• Description:

  Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity) . May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity) . Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity) . Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3'.

• Specifications:

  Western blot: 1:1000

• UniProt:

  Q9BT81

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SOX7 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 319-353 amino acids from the C-terminal region of human SOX7.

• Clonality:

  Polyclonal

• Isotype:

  Ig

• Applications:

  WB, ELISA

• Purity:

  Antigen affinity

• Format:

  Antigen affinity purified

• Buffer:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution:

  Aliquot the SOX7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This SOX7 antibody is available for research use only.

• Storage Conditions:

  Aliquot the SOX7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes:

  Titration of the SOX7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• Prediction Reactivity:

  Mouse

• CAS Number:

  9007-83-4

• Image Legend:

  Western blot analysis of lysate from 1) HCT116 cell line and 2) human heart tissue using SOX7 antibody at 1:1000. Predicted molecular weight: 42/49 kDa (isoforms 1/2) .