Ephb1 Antibody

CAT: 0800-F52891-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
CAT#:0800-F52891-0.08MLSize:0.08 mL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q8CBF3
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
This mouse Ephb1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 304-339 amino acids from the Central region of mouse Ephb1.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Ephb1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Ephb1 antibody is available for research use only.
Storage Conditions
Aliquot the Ephb1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Ephb1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Human
Image Legend
Western blot analysis of lysate from mouse 1) NIH3T3 cell line, 2) brain, 3) heart, 4) pancreas and 5) rat brain tissue lysate using Ephb1 antibody at 1:1000.
Product Datasheet
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