CDH1 Antibody

• Description:

  Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

• Specifications:

  IHC (Paraffin) : 1:25, Western blot: 1:1000

• UniProt:

  P12830

• Host:

  Mouse

• Reactivity:

  Human, Mouse

• Immunogen:

  Purified His-tagged protein was used to produced this monoclonal CDH1 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG1 k

• Clone:

  813CT11.1.3

• Applications:

  IHC, WB, ELISA

• Purity:

  Purified

• Format:

  Purified

• Buffer:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution:

  Aliquot the CDH1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This CDH1 antibody is available for research use only.

• Storage Conditions:

  Aliquot the CDH1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes:

  Titration of the CDH1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• CAS Number:

  9007-83-4

• Location:

  Cytoplasmic, membranous

• Image Legend:

  Immunohistochemical analysis of paraffin-embedded human stomach using CDH1 antibody at 1:25 dilution.