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ASIC1 Antibody / ACCN2

CAT: 0800-F51622-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F51622-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ACCN2 / ASIC1 is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100, Flow Cytometry: 1:10-1:50
UniProt
P78348
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 500-526 from the human protein was used as the immunogen for this ASIC1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, FACS, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ASIC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ASIC1 antibody is available for research use only.
Storage Conditions
Aliquot the ASIC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ASIC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Chicken, Mouse, Rat
Location
Cytoplasmic
Image Legend
Western blot analysis of ASIC1 antibody and human CEM lysate. Predicted molecular weight ~59 kDa.

UniProtKB · P78348

Acid-sensing ion channel 1

ASIC1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P78348
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ASIC1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ASIC1
EC number
—
Processing
—
Secondary accessions
A3KN86, E5KBL7, P78349, Q96CV2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumSodium

Biological process

Calcium transportIon transportSodium transportTransport

Cellular component

Cell membraneCell projectionMembranePostsynaptic cell membraneSynapse

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Ion channelSodium channel

Domain

TransmembraneTransmembrane helix

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NBP3-28257CL1Human Monoclonal ACCN2 Antibody (Regeneron patent anti-ASIC1) [CoraFluor 1]
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