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ASIC1 Antibody

CAT: 0800-RQ5564Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ5564Size:100 µg
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Description
Acid-sensing ion channel 1 (ASIC1) also known as amiloride-sensitive cation channel 2, neuronal (ACCN2) or brain sodium channel 2 (BNaC2) is a protein that in humans is encoded by the ASIC1 gene. It is mapped to 12q13.12. This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described.
CAS Number
9007-83-4
Specifications
Western blot: 0.25-0.5 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P78348
Host
Rabbit
Reactivity
Human
Immunogen
A human recombinant protein (amino acids H163-C528) was used as the immunogen for the ASIC1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the ASIC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ASIC1 antibody is available for research use only.
Storage Conditions
After reconstitution, the ASIC1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the ASIC1 antibody should be determined by the researcher.
Image Legend
Western blot testing of human ThP-1 cell lysate with ASIC1 antibody. Predicted molecular weight ~60 kDa.

UniProtKB · P78348

Acid-sensing ion channel 1

ASIC1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P78348
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ASIC1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ASIC1
EC number
—
Processing
—
Secondary accessions
A3KN86, E5KBL7, P78349, Q96CV2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumSodium

Biological process

Calcium transportIon transportSodium transportTransport

Cellular component

Cell membraneCell projectionMembranePostsynaptic cell membraneSynapse

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Ion channelSodium channel

Domain

TransmembraneTransmembrane helix

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