NIK Antibody (Nck-interacting kinase)

NIK Antibody (Nck-interacting kinase)

• Description: HGK/NIK, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK/NIK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.
• CAS Number: 9007-83-4
• UniProt: O95819
• Host: Rabbit
• Immunogen: A portion of amino acids 618-649 from the human protein was used as the immunogen for this NIK antibody.
• Clonality: Polyclonal
• Isotype: Ig
• Applications: WB, ELISA
• Format: Purified
• Buffer: In 1X PBS, pH 7.4, with 0.09% sodium azide
• Reconstitution: Aliquot the NIK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This NIK antibody is available for research use only.