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BIK Antibody / BCL2-interacting killer

CAT: 0800-R32211Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32211Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bcl-2-interacting killer is a protein that in humans is encoded by the BIK gene. This gene is mapped to 22q13.31. The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, IHC (FFPE) : 0.5-1 µg/mL, FACS: 1-3ug/10^6 cells
UniProt
Q13323
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 1-123 of human BIK were used as the immunogen for the BIK antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the BIK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This BIK antibody is available for research use only.
Storage Conditions
After reconstitution, the BIK antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the BIK antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of 1) rat spleen, 2) rat stomach, 3) rat intestine, 4) human MCF7, 5) human A549 and 6) human SKOV lysate with BIK antibody. Expected molecular weight ~18 kDa but routinely observed at 18-22 kDa.

UniProtKB · Q13323

Bcl-2-interacting killer

BIK_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13323
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BIK
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q16582, Q6FH93
Protein keywords

Biological process

Apoptosis

Cellular component

MembraneMitochondrion

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

PTM

Ubl conjugation
Product Datasheet
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