BACE Antibody

• Description:

  Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.

• Specifications:

  Western blot: 1:1000

• UniProt:

  P56817

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  A portion of amino acids 476-501 from the human protein was used as the immunogen for this BACE antibody.

• Clonality:

  Polyclonal

• Isotype:

  Ig

• Applications:

  WB, ELISA

• Purity:

  Purified

• Format:

  Purified

• Buffer:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution:

  Aliquot the BACE antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This BACE antibody is available for research use only.

• Storage Conditions:

  Aliquot the BACE antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes:

  Titration of the BACE antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• Prediction Reactivity:

  Rat, Bovine

• CAS Number:

  9007-83-4

• Image Legend:

  Western blot analysis of BACE antibody and mouse cerebellum tissue lysate.