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MUSK Antibody

CAT: 0800-F50653-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F50653-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MuSK activates signaling cascades responsible for many aspects of synapse formation, including the organization of the postsynaptic membrane, synapse-specific transcription, and presynaptic differentiation. MuSK also mediates agrin-induced aggregation of acetylcholine receptors at the mature vertebrate neuromuscular junction and also during synapse formation. It has been shown that a majority of AChR Ab-seronegative myasthenia gravis patients possess serum autoantibodies against MuSK.
CAS Number
9007-83-4
UniProt
O15146
Host
Rabbit
Immunogen
This MUSK antibody was produced from rabbits immunized with human MUSK recombinant protein.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS, IF, ELISA
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the MUSK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MUSK antibody is available for research use only.

UniProtKB · O15146

Muscle, skeletal receptor tyrosine-protein kinase

MUSK_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15146
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MUSK
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
Q32MJ8, Q32MJ9, Q5VZW7, Q5VZW8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Cellular component

Cell membraneMembranePostsynaptic cell membraneSynapse

Disease

Congenital myasthenic syndromeDisease variant

Molecular function

Developmental proteinKinaseMuscle proteinReceptorTransferaseTyrosine-protein kinase

Biological process

Differentiation

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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