FGFR Antibody

• Description:

  FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome.

• Specifications:

  Western blot: 1:1000

• UniProt:

  P11362

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A portion of amino acids 441-470 from the human protein was used as the immunogen for this FGFR antibody.

• Clonality:

  Polyclonal

• Isotype:

  Ig

• Applications:

  WB, ELISA

• Purity:

  Antigen affinity

• Format:

  Antigen affinity purified

• Buffer:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution:

  Aliquot the FGFR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This FGFR antibody is available for research use only.

• Storage Conditions:

  Aliquot the FGFR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes:

  Titration of the FGFR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• Prediction Reactivity:

  Chicken, Mouse, Rat

• CAS Number:

  9007-83-4

• Image Legend:

  Western blot analysis of FGFR antibody and 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR1 gene (2) . Predicted molecular weight: 75-160 kDa depending on glycosylation level.