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FASN Antibody

CAT: 0800-F50414-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F50414-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FASN (Fatty acid synthase) is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Immunofluorescence: 1:10-1:200, IHC (Paraffin) : 1:10-1:50, Flow Cytometry: 1:10-1:50
UniProt
P49327
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 942-973 from human Fatty acid synthase was used as the immunogen for this FASN antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IF, WB, IHC, FACS, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the FASN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This FASN antibody is available for research use only.
Storage Conditions
Aliquot the FASN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the FASN antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
Western blot analysis of FASN antibody in Ramos lysate. Predicted molecular weight ~ 270 kDa.

UniProtKB · P49327

Fatty acid synthase

FAS_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P49327
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FASN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.1.85
Processing
—
Secondary accessions
Q13479, Q16702, Q4LE83, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphopantetheinePhosphoproteinS-nitrosylationUbl conjugation

Cellular component

Cytoplasm

Biological process

Fatty acid biosynthesisFatty acid metabolismLipid biosynthesisLipid metabolism

Molecular function

HydrolaseLyaseMultifunctional enzymeOxidoreductaseTransferase

Ligand

NADNADPPyridoxal phosphate

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