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Fas Antibody

CAT: 0800-F54056-0.1MLSize: 0.1 mLDry Ice: NoHazardous: No
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CAT#:0800-F54056-0.1MLSize:0.1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro) . [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P25445
Host
Mouse
Reactivity
Human, Rat
Immunogen
A human recombinant protein was used as the immunogen for this Fas antibody.
Clonality
Monoclonal
Isotype
LgG2b
Clone
8C1-B9-F12
Applications
WB
Purity
Protein G affinity
Format
Purified
Buffer
Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Reconstitution
Store the Fas antibody at -20oC.
Limitations
This Fas antibody is available for research use only.
Storage Conditions
Store the Fas antibody at -20°C.
Formulation
In PBS with 50% glycerol and 0.03% ProClin 300
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Fas antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of 1) human K562, 2) human Jurkat, 3) rat brain and 4) human Ramos lysates using Fas antibody at 1:1000. Predicted molecular weight: ~38 kDa (unmodified), 40-55 kDa (glycosylated) .

UniProtKB · P25445

Tumor necrosis factor receptor superfamily member 6

TNR6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P25445
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FAS
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A9UJX4, B6VNV4, Q14292, Q14293, Q14294, Q14295, Q16652, Q5T9P1, Q5T9P2, Q5T9P3, Q6SSE9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Molecular function

Calmodulin-bindingReceptor

Cellular component

Cell membraneMembraneSecreted

Disease

Disease variant

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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