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PINK1 Antibody

CAT: 0800-F49623-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F49623-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6) . Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
Q9BXM7
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 118-147 from the human protein was used as the immunogen for this PINK1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Store at 4oC for up to one month. For long term, aliquot the PINK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PINK1 antibody is available for research use only.
Storage Conditions
Store at 4°C for up to one month. For long term, aliquot the PINK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the PINK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of lysate from human placenta tissue, using Park6/ PINK1 antibody diluted at 1:1000. Predicted molecular weight: 60-70 kDa

UniProtKB · Q9BXM7

Serine/threonine-protein kinase PINK1, mitochondrial

PINK1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BXM7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PINK1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
Precursor
Secondary accessions
Q8N6T9, Q8NBU3, Q96DE4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Biological process

Autophagy

Cellular component

CytoplasmMembraneMitochondrionMitochondrion inner membraneMitochondrion outer membrane

Disease

Disease variantNeurodegenerationParkinson diseaseParkinsonismPrimary mitochondrial disease

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

Domain

Transit peptide

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