Products for Research Use Only
RegisterLogin

APP Antibody / Amyloid beta

CAT: 0800-F49576-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-F49576-0.08MLSize:0.08 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G (O) and JIP. Inhibits G (o) alpha ATPase activity (By similarity) . Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50, Flow Cytometry: 1:10-1:50
UniProt
P05067
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 29-61 from the human Amyloid beta protein was used as the immunogen for this APP antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, FACS, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the APP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This APP antibody is available for research use only.
Storage Conditions
Aliquot the APP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the APP antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Primate
Image Legend
Western blot analysis APP antibody and 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the APP gene (2) . Predicted molecular weight 79~120 kDa depending on glycosylation level.

UniProtKB · P05067

Amyloid-beta precursor protein

A4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05067
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
APP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
APP
EC number
—
Processing
Precursor
Secondary accessions
B2R5V1, B4DII8, D3DSD1, D3DSD2, D3DSD3, P09000, P78438, Q13764, Q13778, Q13793, Q16011, Q16014, Q16019, Q16020, Q6GSC0, Q8WZ99, Q9BT38, Q9UC33, Q9UCA9, Q9UCB6, Q9UCC8, Q9UCD1, Q9UQ58
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Alzheimer diseaseAmyloidosisDisease variantNeurodegeneration

Cellular component

AmyloidCell membraneCell projectionCoated pitCytoplasmCytoplasmic vesicleEndoplasmic reticulumEndosomeGolgi apparatusMembraneNucleusSecreted

Biological process

ApoptosisCell adhesionEndocytosisNotch signaling pathway

Ligand

CopperIronMetal-bindingZinc

PTM

Disulfide bondGlycoproteinIsopeptide bondOxidationPhosphoproteinProteoglycanSulfationUbl conjugation

Molecular function

Heparin-bindingProtease inhibitorSerine protease inhibitor

Domain

SignalTransmembraneTransmembrane helix

Related Products

CatalogName
V5427SAF-100UGAmyloid beta Antibody / APP
V5428SAF-100UGBeta Amyloid Antibody / APP
V5428-100UGBeta Amyloid Antibody / APP
V5428-20UGBeta Amyloid Antibody / APP
V5427-20UGAmyloid beta Antibody / APP
R31517Amyloid beta Antibody / APP
V5427-100UGAmyloid beta Antibody / APP
V5746-100UGRecombinant Amyloid beta Antibody / APP
V5746-20UGRecombinant Amyloid beta Antibody / APP
V5746SAF-100UGRecombinant Amyloid beta Antibody / APP

Alternative Products

CatalogName
10R-A124abeta Amyloid antibody
GWB-B08950Beta Amyloid, Antibody
GTR18311698-01Amyloid Beta Antibody

Popular Products