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XRCC1 Antibody

CAT: 0800-F49231-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F49231-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1:25, Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100, Flow Cytometry: 1:10-1:50
UniProt
P18887
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 407-435 from the human protein was used as the immunogen for this XRCC1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, FACS, IF, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the XRCC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This XRCC1 antibody is available for research use only.
Storage Conditions
Aliquot the XRCC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the XRCC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Nuclear
Image Legend
Immunofluorescent analysis of A549 cells using XRCC1 antibody at 1:25. Alexa Fluor 488-conjugated secondary was used (green) . Cytoplasmic actin was counterstained with Dylight Fluor 554 conjugated Phalloidin (red) .

UniProtKB · P18887

DNA repair protein XRCC1

XRCC1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P18887
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
XRCC1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q6IBS4, Q9HCB1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

ChromosomeNucleus

Biological process

DNA damageDNA repair

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Disease

Neurodegeneration

Domain

Repeat

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