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XRCC4 Antibody

CAT: 0800-R32215Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32215Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
X-ray repair cross-complementing protein 4 is a protein that in humans is encoded by the XRCC4 gene. In addition to humans, the XRCC4 protein is also expressed in many other metazoans, fungi and in plants. The X-ray repair cross-complementing protein 4 is one of several coreproteins involved in the non-homologous end joining (NHEJ) pathway to repair DNA double strand breaks (DSBs) . Since XRCC4 is the key protein that enables interaction of LigIV to damaged DNA and therefore ligation of the ends, mutations in the XRCC4 gene were found to cause embryonic lethality in mice and developmental inhibition and immunodeficiency in humans. Furthermore, certain mutations in the XRCC4 gene are associated with an increased risk of cancer.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
Q13426
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids ESEISQEADDMAMEKGKYVGELRKALL of human XRCC4 were used as the immunogen for the XRCC4 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the XRCC4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This XRCC4 antibody is available for research use only.
Storage Conditions
After reconstitution, the XRCC4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the XRCC4 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
Western blot testing of human 1) SW620 and 2) A431 cell lysate with XRCC4 antibody. Predicted molecular weight: 35-38/55 kDa (unmodified/phosphorylated) .

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