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Phospho-IKK beta Antibody (pY609)

CAT: 0800-F48824-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F48824-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine) .
CAS Number
9007-83-4
Specifications
Dot blot: 1:500
UniProt
O14920
Host
Rabbit
Reactivity
Human
Immunogen
This phospho-IKK beta antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY609 of human IKKB.
Clonality
Polyclonal
Isotype
Ig
Applications
DB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the phospho-IKK beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This phospho-IKK beta antibody is available for research use only.
Storage Conditions
Aliquot the phospho-IKK beta antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the phospho-IKK beta antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Bovine, Mouse
Image Legend
Dot blot analysis of phospho-IKK beta antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.

UniProtKB · O14920

Inhibitor of nuclear factor kappa-B kinase subunit beta

IKKB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14920
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IKBKB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
I-kappa-B-kinase beta, IKK-B, IKK-beta, IkBKB
EC number
2.7.11.10
Processing
—
Secondary accessions
B4DZ30, B4E0U4, O75327
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationHydroxylationIsopeptide bondPhosphoproteinS-nitrosylationUbl conjugation

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmMembraneNucleus

Disease

Disease variantSCID

Biological process

Host-virus interaction

Molecular function

KinaseSerine/threonine-protein kinaseTransferase
Product Datasheet
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