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NeuroD1 Antibody

CAT: 0800-F47843-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F47843-0.08MLSize:0.08 mL
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Description
NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6) . MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q13562
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A portion of amino acids 318-348 from the human protein was used as the immunogen for this NeuroD1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the NeuroD1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This NeuroD1 antibody is available for research use only.
Storage Conditions
Aliquot the NeuroD1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the NeuroD1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
NeuroD1 antibody western blot analysis in 1) Y79 cell line, 2) mouse cerebellum and 3) rat brain tissue lysate.

UniProtKB · Q13562

Neurogenic differentiation factor 1

NDF1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13562
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NEUROD1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
NeuroD, NeuroD1
EC number
—
Processing
—
Secondary accessions
B2R9I8, F1T0E1, O00343, Q13340, Q5U095, Q96TH0, Q99455, Q9UEC8
Protein keywords

Molecular function

ActivatorDevelopmental proteinDNA-binding

Cellular component

CytoplasmNucleus

Disease

Diabetes mellitusDisease variant

Biological process

DifferentiationNeurogenesisTranscriptionTranscription regulation

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

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