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Aconitase 2 Antibody

CAT: 0800-F47297-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F47297-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ACO2/Aconitase 2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15 (PRSS15), also known as Lon protease, after oxidative modification.
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1000, IHC (Paraffin) : 1:10-1:50
UniProt
Q99798
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A portion of amino acids 438-467 from the human protein was used as the immunogen for this Aconitase 2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Aconitase 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Aconitase 2 antibody is available for research use only.
Storage Conditions
Aliquot the Aconitase 2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Aconitase 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Bovine, Pig
Location
Cytoplasmic, granular
Image Legend
Western blot testing of human 293 cell lysate with Aconitase 2 antibody at 1:1000. Predicted molecular weight ~85 kDa.

UniProtKB · Q99798

Aconitate hydratase, mitochondrial

ACON_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q99798
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ACO2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Aconitase
EC number
4.2.1.3
Processing
Precursor
Secondary accessions
O75809, Q5JZ41, Q6FHX0, Q8TAQ6
Protein keywords

Ligand

4Fe-4SIronIron-sulfurMetal-binding

PTM

AcetylationPhosphoprotein

Technical term

Direct protein sequencingProteomics identificationReference proteome

Disease

Disease variantNeurodegeneration

Molecular function

Lyase

Cellular component

Mitochondrion

Domain

Transit peptide

Biological process

Tricarboxylic acid cycle
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